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New screening tool for IVF embryos leads to birth of healthy children

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first_img IVF embryos in a dish. Sang Tan/AP New research may potentially improve the chances of success for some women and couples looking to get pregnant through in vitro fertilization.IVF has been around for nearly four decades, but the procedure still has a relatively low success rate due, in large part, to genetic and chromosomal mutations in embryos that can be difficult to detect. While various methods have been developed to identify such mutations for selecting those with the highest chances of resulting in a successful pregnancy, their accuracy remains challenging.In a study published Monday in the Proceedings of the National Academy of Sciences, researchers from the United States and China describe a method that they said for the first time combines the latest in gene sequencing technologies with other genomic-based strategies to identify those mutations, leading to better detection and allowing for the improved selection of human embryos for IVF.advertisement Gene studies shed light on women’s reproductive health One reason for the relatively low IVF success rate — from as high as about 40 percent for women under the age of 35 to as low as about 12 percent for women over the age of 40 — is what is known as a chromosomal aneuploidy, when a cell does not have the normal count of 46 chromosomes. Another factor are alterations in a single gene, or when a gene is missing.Separate genetic technologies can detect aneuploidies or single-point mutations, but they had not been able to detect both abnormalities at the same time. The new method — dubbed MARSALA, short for mutated allele revealed by sequencing with aneuploidy and linkage analyses — combines both into one simple approach. The researchers tested MARSALA on two couples undergoing IVF. Both cases involved parents in their early 30s — one in which the father harbored a genetic mutation that caused multiple bony spurs and lumps to grow in his body; another in which the mother carried a recessive mutation on one of her X chromosomes that she had already passed on to one son, who now suffers from hair, sweat, and skin abnormalities. By using MARSALA, the researchers selected mutation-free embryos for the two couples, each resulting in the birth of a healthy girl free of the parents’ genetic problems.The scientists noted that the method is limited to parents who already have known genetic disorders, and cannot be used for the general population. But in those cases, they write, “MARSALA has improved the precision” of diagnostic and screening techniques for IVF embryos.Not all reproductive medicine doctors agree. Dr. Michael Alper, medical director of Boston IVF, said MARSALA could have a place in the clinic for some couples. But Dr. Francesco Fiorentino, president and CEO of Genoma Molecular Genetics Laboratory in Rome, said the method mostly serves to “simplify the laboratory workflow” without offering much improvement at the patient level.Fiorentino noted that MARSALA still can’t pick up on a phenomenon called mosaicism, in which a person’s cells have a different genetic makeup — a common problem in IVF-derived embryos. This, he said, undermines “the reliability of the results.” Teen birth rates plunge to record low Related:center_img In the LabNew screening tool for IVF embryos leads to birth of healthy children Related: Two healthy babies were born after the method was used to select embryos.Dr. Jason Franasiak, an infertility specialist at the Rutgers Robert Wood Johnson Medical School, described the technique as a “safe, accurate, and cost-efficient means for performing comprehensive chromosome screening, and single-gene defect diagnosis.” Franasiak was not involved in the study.advertisement By Tony Fong Dec. 28, 2015 Reprints Tags geneticsIVFreproductive medicinelast_img

Two airline passengers fined $17,000 for faking negative COVID tests

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first_imgAdvertisementAnyone failing to abide by these regulations can face a fine of up to $5,000 per violation, reported CNN.“Transport Canada will continue to investigate incidents reported to the department and will not hesitate to take enforcement action where it is warranted,” the agency said.The-CNN-Wire™ & © 2021 Cable News Network, Inc., a WarnerMedia Company. All rights reserved. OTTAWA, Ontario (CNN) – Two airline passengers were fined a combined $17,000 by Transport Canada after allegedly presenting fake COVID-19 tests before they flew back to Canada.The passengers were fined $10,000 and $7,000 respectively for “presenting a false or misleading COVID-19 test and for making a false declaration about their health status,” according to a news release from Transport Canada.The company said the passengers had boarded a flight from Mexico to Montreal on Jan. 23 after they tested positive for COVID-19 a few days prior to their flight.Travelers must present a negative COVID-19 test within 72 hours of boarding a flight to Canada or provide proof of a positive result between 14 and 90 days prior to arrival, according to current regulations. Delta temporarily fills middle seats after flight cancelations April 6, 2021 AdvertisementTags: airlineCanadafake covid-19 test Canadian lawmaker caught naked during virtual meeting April 16, 2021 ‘Only for the wealthy’: Airlines slam UK foreign travel rules April 9, 2021 Advertisementcenter_img AdvertisementRecommended ArticlesBrie Larson Reportedly Replacing Robert Downey Jr. As The Face Of The MCURead more81 commentsGal Gadot Reportedly Being Recast As Wonder Woman For The FlashRead more29 comments Advertisement Some turn to Canada for cheaper prescriptions May 6, 2021 RELATEDTOPICS AdvertisementDC Young Fly knocks out heckler (video) - Rolling OutRead more6 comments'Mortal Kombat' Exceeded Expectations Says WarnerMedia ExecutiveRead more2 commentsDo You Remember Bob's Big Boy?Read more1 commentsKISS Front Man Paul Stanley Reveals This Is The End Of KISS As A Touring Band, For RealRead more1 commentslast_img

Kim-Medvedev Summit Canceled

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first_img RELATED ARTICLESMORE FROM AUTHOR North Korea tries to accelerate building of walls and fences along border with China News News There are signs that North Korea is running into serious difficulties with its corn harvest Entire border patrol unit in North Hamgyong Province placed into quarantine following “paratyphoid” outbreak AvatarKwon Eun Kyoung News center_img News Kim-Medvedev Summit Canceled By Kwon Eun Kyoung - 2011.06.29 1:44pm The summit between Russian President Dmitry Medvedev and Kim Jong Il, which was allegedly set to take place at the beginning of July, has apparently been cancelled.A South Korean high official revealed the news on the 28th, saying, “It’s my understanding that the summit between Chairman Kim Jong Il and President Dmitry Mevedev was scheduled to take place in Russia’s Far Eastern region of Vladivostok on June 30 or July 1. We have no idea yet why the talks were canceled.” A Russian government source also confirmed, “The Russia-North Korea talks planned for the end of this month or beginning of next month have been cancelled. Of course maybe the North Korean side will change the when or why again, but as it stands, the chance of the talks not taking place is above 80%.” A diplomatic source in Moscow speculated “It could be that North Korea canceled the plan because at the final stage of confirming the agenda and possible results of the summit they were unable to reach a conclusion.” There have been several cases of Kim Jong Il allegedly canceling plans to visit Russia in the past. Several Japanese and Russian media outlets reported that the two leaders were going to meet in Vladivostok while President Medvedev is there checking on preparations for next year’s APEC forum. SHARE Facebook Twitterlast_img

UPDATE: Vancouver Police locate missing teen

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first_imgUPDATE: Vancouver Police locate missing teenPosted by ClarkCountyToday.comDate: Monday, September 28, 2020in: Newsshare 0 13-year-old found safe Sept. 28UPDATE: Nash has been located and is safe.VANCOUVER — The Vancouver Police Department (VPD) is asking for the public’s assistance in locating a missing child by the name of Nash H.L. Modin. Nash is described as a 13-year-old caucasian male, 5-feet-6-inches, 120 pounds, blue eyes, and brown hair. The Vancouver Police Department (VPD) is asking for the public's assistance in locating a missing child by the name of Nash H.L. Modin.The Vancouver Police Department (VPD) is asking for the public’s assistance in locating a missing child by the name of Nash H.L. Modin. Nash was last seen wearing dark colored pants and a grey sweatshirt with dark blue sleeves. Anyone with information is asked to contact VPD, via 9-1-1 or 3-1-1.Information provided by the Vancouver Police Department.AdvertisementThis is placeholder textTags:Clark CountyLatestVancouvershare 0 Previous : Vancouver motel fire claims the life of 32-year-old man Next : Give More 24! sets record with close to $2.9 million in donationsAdvertisementThis is placeholder textlast_img

Jamaica Booth at Trade Expo in China Attracting Many Visitors

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first_imgRelatedJamaica Booth at Trade Expo in China Attracting Many Visitors Advertisements FacebookTwitterWhatsAppEmail Minister of Industry, Investment and Commerce, Hon. Karl Samuda, says the Jamaica booth at the Shanghai 2010 trade expo, in China, has been well represented, attracting some 25,000 visitors daily, since the start of the event on May 1.“The CARICOM (Caribbean Community) pavilion apparently is a very attractive pavilion, attracting some 27,000 visitors over the two-day period, June 2 to 4,” he told journalists on June 15, during a press conference at his office, in New Kingston.The trade show, which is regarded as the largest trade expo in world history, will last until October 31, and is expected to attract millions of visitors over the five-month period.The Minister said reports coming out of China suggested that nearly all of the visitors to the CARICOM pavilion have also visited the Jamaican booth.“I’m told the Jamaica booth is very attractive and very exciting and we expect that the number of visitors will increase by the summer,” he said.However, Mr. Samuda said Jamaica has had its difficulties in China, as a result of the May 24 unrest in West Kingston.“A number of persons in Shanghai have expressed great concern and, in fact, in some instances, we were advised of persons who were having second thoughts with Jamaica as an investment destination,” he informed.He said as a result, a team from Jamaica will be visiting Shanghai in July to address the concerns of business interests in the Asian country.“We intend to meet with a number of potential investors and to hold discussions with the community in China that would be interested in partnering with us in our economic development,” the Minister said.“Our aim is to assure them that Jamaica is safer today than it has been for a long time, because we have seen a massive reduction in the murder rate and there is no question that the direction we have taken is the appropriate direction, and we are coming to grips with our difficulties in fighting crime and violence,” he added.President of Jamaica Promotions Corporation (JAMPRO), Sancia Bennett-Templer, said the organisation has already been in touch with some of the “influencers” in China, with a view to reclaiming business interests in the country.“We are also thinking of inviting to Jamaica, some of the influencers, particularly in the ICT and film industries, because those are the two industries which will be most affected by the unrest,” she informed.“We are going business to business and that’s a very effective methodology for us,” Mrs. Bennett-Templer added.In the meantime, the Minister said a number of Jamaican products have been doing well at the expo, including coffee, books, apparel and sauces. He said the Jamaican Reggae Room is also quite popular. RelatedJamaica Booth at Trade Expo in China Attracting Many Visitorscenter_img RelatedJamaica Booth at Trade Expo in China Attracting Many Visitors Jamaica Booth at Trade Expo in China Attracting Many Visitors CultureJune 17, 2010last_img

Samsung suffers in Q2 guidance

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first_img Previous ArticleVodafone adds Alcatel-Lucent to Project Spring rosterNext ArticleIntel, Samsung among founders of new IoT consortium Home Samsung suffers in Q2 guidance Richard Handford Google renueva Android y muestra novedades en IA Tags AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 08 JUL 2014 Samsung boosts logic chip investment by $34B FinancialSamsungcenter_img Samsung cited a strong Korean won, a decline in smartphone and tablet shipments and increased marketing expenses to explain a fall in sales and operating profit in its guidance for Q2 2014.The company estimated that operating profit for April-June fell by 24.5 per cent to KRW7.2 trillion ($7.12 billion) compared to the same period in 2013. And the number one handset vendor forecast sales of KRW52 billion, representing a 9.5 per cent drop from Q2 2013.Q2 disappointment was not unexpected given a recent comment from CFO Lee Sang Hoon that Q2 will be “not that good”.However, the company said the outlook for the current quarter (Q3, 2014) is more optimistic.As well as a strong Korean currency, the company said the weak Q2 guidance was caused by lower than expected device shipments thanks to competition in Europe and China, as well as increased marketing costs as the company worked to reduce inventory buildup ahead of the Q3 peak season and new model launches.In turn, the weak demand for devices had a knock-on effect with Samsung’s Display and System LSI businesses.As well as fierce competition, the company cited slower growth in demand from consumers to explain lower shipments.In China, inventory levels increased in Q2 due to weak seasonal demand, a fall in 3G demand as consumers geared up for 4G in the second half, as well as greater competition from local players.The company maintained a high level of market share (around 40 per cent) in Europe but as in China there was a surge in channel inventory due to weak demand.For tablets, shipments declined more than expected because of weak overall market demand. Unlike smartphones, lack of operator subsidies led to low replacement demand for tablets.The demand for five-to-six inch smartphones also cannibalised the demand for seven-to-eight inch tablets, the company noted.Samsung sounded slightly more optimistic in its forecast for Q3. It expects additional appreciation of the won to be “limited” compared to the second quarter.Also, the company expects marginal marketing expenses related to inventory reduction and “cautiously expects a more positive outlook in the third quarter led by increased shipments of the coming release of its new smartphone lineup”.Samsung is also looking forward to increased display panel shipments, with higher shipments of devices to have a positive impact on the earnings growth. KT makes LG Electronics trade-in move Related Asia Author Richard is the editor of Mobile World Live’s money channel and a contributor to the daily news service. He is an experienced technology and business journalist who previously worked as a freelancer for many publications over the last decade including... Read more last_img

VimpelCom confirms Zimbabwe sale

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first_img Steve works across all of Mobile World Live’s channels and played a lead role in the launch and ongoing success of our apps and devices services. He has been a journalist...More Read more Steve Costello VimpelCom is set to sell its operations in Zimbabwe to a state-owned internet service provider (ISP).The deal has previously been mooted, with speculation that VimpelCom had found a foreign investor to buy the stake, before such a deal was blocked in order to allow ISP ZARnet into the frame.Global Telecom Holding, a company 51.9 per cent owned by VimpelCom, is to sell its stake in Telecel International for $40 million. In turn, Telecel owns 60 per cent of Telecel Zimbabwe.With VimpelCom having been an investor in Zimbabwe for a number of years, $40 million is hardly a handsome price (earlier this year a mobile infrastructure investment total of $237 million since 1998 was claimed). Its operation has also not been without headaches: earlier this year it had its licence suspended, although it subsequently got a reprieve.The transfer to ZARnet, which is wholly owned by the government through the ICT ministry, will take place “after customary conditions are satisfied”.VimpelCom has been in the process of disposing of a number of assets owned through Global Telecom Holding, including businesses in Algeria – after a long dispute – Burundi, Central African Republic and Canada. Money Previous ArticleMTS gets more optimistic about full-yearNext ArticlePandora to acquire $75M worth of assets from Rdio Related Zimbabwe reopens mobile money cash buying Authorcenter_img Home VimpelCom confirms Zimbabwe sale Zimbabwe mobile money cash-in services surge AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 18 NOV 2015 Zimbabwe slaps strict limits on mobile money Tags Global Telecom HoldingTelecelVimpelComZARnetZimbabwelast_img

Google to start charging for apps after EU fine

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first_img Related HomeAppsNews Google to start charging for apps after EU fine Australia watchdog moves to open up app market AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 17 OCT 2018 Author Google shuts Shopping app Diana is Mobile World Live's US Editor, reporting on infrastructure and spectrum rollouts, regulatory issues, and other carrier news from the US market. Diana came to GSMA from her former role as Editor of Wireless Week and CED Magazine, digital-only... Read more Diana Goovaerts center_img Google laid out plans to stop bundling preinstalled apps with its Android platform and instead charge manufacturers a fee to licence its apps, as part of a bid to avoid additional fines from European Union (EU) regulators.The European Commission (EC) in July issued a €4.3 billion fine to Google after it found the tech giant abused the dominant position of its Android platform to force manufacturers to install its apps on devices. It gave the tech giant until 28 October to change its business practices or face further penalties.In a blog post, Google SVP of platforms and ecosystems Hiroshi Lockheimer noted Google has filed to appeal the EC’s decision, but is introducing changes to comply with the ruling while the appeal is pending.Starting 29 October, Google said it will offer individual paid licences for its Search app and Chrome browser, as well as a bundled licence for the rest of its app suite, which includes YouTube, Maps and Gmail, for manufacturers who want to preinstall the apps on devices shipped to the EU. Lockheimer did not say how much the new licences will cost, but noted the funds would contribute to the continued development and free distribution of its Android operating system.Google also said it will now allow device makers to build modified or “forked” versions of its Android platform for smartphones and tablets offered in the EU. The move reverses a previous policy which blocked manufacturers from offering its suite of apps on such devices.The changes bring to fruition a warning from Google CEO Sundar Pichai in July that the company may have to start charging for its apps following the EC decision, which he said “upset the careful balance that we have struck with Android”. Subscribe to our daily newsletter Back Tags Apps Serie A, Google give piracy apps the boot Previous ArticleHuawei targets smartphone supremacy with Mate lineNext ArticleDtac to bid in 900MHz auction, reports Q3 loss appsGooglelicence feelast_img

Abu-boos

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first_imgAs far as season openers go, Phil Mickelson and Rory McIlroy gave fans plenty of reasons for optimism in Abu Dhabi. Sure, a case could be made that they both left the desert lamenting their mental mistakes – Phil the double-hit in the final round that led to a triple bogey, Rory the two-shot penalty Saturday for taking an improper drop. But even though they finished a shot behind surprise winner Pablo Larrazabal, the biggest takeaway from Abu Dhabi was the play of two of golf’s biggest stars. Considering their 2014 objectives, it was an auspicious start. Of course, Mickelson enters every year bubbling with enthusiasm, effusing about his new equipment, believing that, yes, this will be his best year yet. And who knows? At age 44, with the prospect of the career grand slam looming, it just might. But even more encouraging than Lefty’s runner-up finish or his new driver was the fact that he traveled nearly 8,500 miles, showed relatively little rust and gave himself a chance to win in the first start of arguably his most important year ever. Supposedly, his 2014 season begins and ends at Pinehurst, where all of his U.S. Open heartache began 15 years ago. The thinking goes that it would then leave his other starts to serve as measuring sticks for his game, with one very green-jacketed exception. If that’s true, if Mickelson’s first few months are just one big preview for the U.S. Open, it sure didn’t seem like it in Abu Dhabi.  He could have collected the fat appearance check, mailed it in for 72 holes, and headed back to San Diego for next week’s domestic debut at home. Instead, he showed his trademark resiliency, erasing a no-birdie opener to shoot 63 on Day 3, rebounding from a double-hit on 13 to post three birdies in his last five holes, showing more than enough over four days to make you believe that he’ll soon pick up a victory on the West Coast swing. “We’re all along for the ride,” a laughing Mickelson told The National. “We’re up, we’re down. We see where it goes.” Over the past year McIlroy’s ride has been even bumpier, which made his week even more promising. Indeed, his T-2 stands in stark contrast to a year ago, when he arrived with much fanfare, looked utterly lost with his new sticks and missed the cut in a fitting opener for the lost year. These days, Rory is smiling again. (Well, except when he’s penalized.) The saunter has returned, as has the confidence and aggressiveness on the course.   Of course, he may have been too easygoing, which led to a crippling penalty for an improper drop on Saturday. He groused about the “stupid rules” in golf, but really he can chalk this up to a brain-dead moment. It was an obvious violation that could have been avoided. Even after a final-round 68 he still seemed miffed by the penalty. “I can’t describe how frustrating it is, and I feel like I’m standing here and I should be 15 under par for the tournament and winning by one. But that’s the way it goes,” he said. “I played the least shots of anyone this week. I can count it as a moral victory more than anything else.” Now, perhaps, he has a little extra fire, but at least he doesn’t feel as though he squandered his last opportunity for a while. Dating to last October, the world No. 7 has finished 11th or better in seven of his last eight starts, including his drought-busting victory at the Australian Open. “I feel good about my game,” he said. “I feel like I’m back to the place that I want to be.” Rest assured, he’s not the only one who left Abu Dhabi feeling that way.last_img

An Avalanche of Education

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first_img Stay Connected with the Daily Roundup. Sign up for our newsletter and get the best of the Beacon delivered every day to your inbox. Email In response to a potential influx of backcountry users this winter, the Friends of the Flathead Avalanche Center (FOFAC) education committee held a meeting to brainstorm how to best prepare for the season and what they could do to keep recreationists as safe as possible.“We realized we needed to up the education,” FOFAC Education Coordinator Meg Killen said. “We don’t want to see accidents, and if they happen, we want to see people are making the right decisions … We want to make sure we’re doing everything we can.”To address the expected increase in backcountry use this winter, FOFAC has added more specific classes this season in addition to its regular avalanche awareness and Avalanche Level 1 and 2 certification courses that are offered every season.New courses include tune-up classes to give students an opportunity to refresh material, partner rescue, motorized Avalanche Level 1 and topics classes, which range from avalanche dogs to ice climbing to a decision-making conversation with professional skier Cody Townsend.“I think it’s an opportunity for folks to learn more,” Killen said. “Even if somebody doesn’t have a whole lot of background knowledge, the more education the better.”While Flathead Avalanche Forecaster Mark Dundas has noticed a steady growth in backcountry use each year, he says the number of avalanche accidents hasn’t kept pace with the user growth.“I don’t know if it’s education — I think that might play a part in it,” he said. “There’s certainly a lot more courses and class offerings that there wasn’t before.”And despite a predicted influx in backcountry travelers this season, Dundas hasn’t noticed an obvious traffic uptick in comparison to last winter.Dundas also points to the Flathead Avalanche Center’s growth in recent years as a possible reason for the low number of incidents. Until roughly five years ago, the center only posted forecasts twice a week and only had a few part-time forecasters. Now, four full-time forecasters post daily forecasts from December through April.With a new weather station on Tunnel Ridge in the Flathead Range, forecasters say it’s filling in data points that were previously a “big, black hole,” in the forecasting region. The station was installed over the summer with funding from FOFAC, while the Mt. Aeneas weather station was installed last year. The stations also help the U.S. Forest Service monitor wildfires and Two Bear Air and other rescue services monitor wind speeds for flying.At the end of December, Dundas says the Flathead forecasting area, which covers the Whitefish, Flathead and Swan mountain ranges and southern Glacier National Park, is either at or above average snow levels, according to area SNOTEL data.Flathead Avalanche forecaster Clancy Nelson says while the snowpack varies across the region, it’s typically deeper in the Swan Range. But despite the generally shallower and colder snowpack in the Whitefish Range, the northern side near the Canadian border has a particularly deep snowpack so far this year.While an atmospheric river event brought warm temperatures and wet, heavy snow and rain, triggering several natural avalanches right before Christmas, Dundas says the snowpack has somewhat stabilized since then and there are now different issues on the horizon.“It created some very large destructive slides and our snowpack is getting beat up from that, but it didn’t have much left to give,” Dundas said. “Our main concern is a persistent slab problem. Buried layers deeper in the snowpack that are hard to trigger but when they do fail, they are much larger, dangerous and more destructive. So that’s our main concern right now.”Dundas traces the persistent layers back to two separate weather events earlier this month. On Dec. 9, a warming event created a “thick, strong crust” surrounded by weak layers, which is now buried four feet deep, while Dec. 22 brought freezing rain and weak snow buried about a foot beneath the snow surface.“These weak layers can fail,” Dundas said. “These are both layers we need to watch and monitor as our snowpack evolves.”“Right now, you might be on the snow surface and everything is fine, but our current problem is buried beneath your feet and it’s a really tough problem to assess even for professional forecasters,” he added. “We always encourage people when we have these hidden dangers below the surface, we default to terrain selections that keep us safe with slopes that are 35 degrees or less and avoiding convexities where slopes roll over.”Forecasters also encourage users to get the appropriate avalanche gear and training, check the avalanche forecast and know how to recognize unstable snow.For the latest forecast or to register for classes, visit [email protected] last_img