IVF embryos in a dish. Sang Tan/AP New research may potentially improve the chances of success for some women and couples looking to get pregnant through in vitro fertilization.IVF has been around for nearly four decades, but the procedure still has a relatively low success rate due, in large part, to genetic and chromosomal mutations in embryos that can be difficult to detect. While various methods have been developed to identify such mutations for selecting those with the highest chances of resulting in a successful pregnancy, their accuracy remains challenging.In a study published Monday in the Proceedings of the National Academy of Sciences, researchers from the United States and China describe a method that they said for the first time combines the latest in gene sequencing technologies with other genomic-based strategies to identify those mutations, leading to better detection and allowing for the improved selection of human embryos for IVF.advertisement Gene studies shed light on women’s reproductive health One reason for the relatively low IVF success rate — from as high as about 40 percent for women under the age of 35 to as low as about 12 percent for women over the age of 40 — is what is known as a chromosomal aneuploidy, when a cell does not have the normal count of 46 chromosomes. Another factor are alterations in a single gene, or when a gene is missing.Separate genetic technologies can detect aneuploidies or single-point mutations, but they had not been able to detect both abnormalities at the same time. The new method — dubbed MARSALA, short for mutated allele revealed by sequencing with aneuploidy and linkage analyses — combines both into one simple approach. The researchers tested MARSALA on two couples undergoing IVF. Both cases involved parents in their early 30s — one in which the father harbored a genetic mutation that caused multiple bony spurs and lumps to grow in his body; another in which the mother carried a recessive mutation on one of her X chromosomes that she had already passed on to one son, who now suffers from hair, sweat, and skin abnormalities. By using MARSALA, the researchers selected mutation-free embryos for the two couples, each resulting in the birth of a healthy girl free of the parents’ genetic problems.The scientists noted that the method is limited to parents who already have known genetic disorders, and cannot be used for the general population. But in those cases, they write, “MARSALA has improved the precision” of diagnostic and screening techniques for IVF embryos.Not all reproductive medicine doctors agree. Dr. Michael Alper, medical director of Boston IVF, said MARSALA could have a place in the clinic for some couples. But Dr. Francesco Fiorentino, president and CEO of Genoma Molecular Genetics Laboratory in Rome, said the method mostly serves to “simplify the laboratory workflow” without offering much improvement at the patient level.Fiorentino noted that MARSALA still can’t pick up on a phenomenon called mosaicism, in which a person’s cells have a different genetic makeup — a common problem in IVF-derived embryos. This, he said, undermines “the reliability of the results.” Teen birth rates plunge to record low Related: In the LabNew screening tool for IVF embryos leads to birth of healthy children Related: Two healthy babies were born after the method was used to select embryos.Dr. Jason Franasiak, an infertility specialist at the Rutgers Robert Wood Johnson Medical School, described the technique as a “safe, accurate, and cost-efficient means for performing comprehensive chromosome screening, and single-gene defect diagnosis.” Franasiak was not involved in the study.advertisement By Tony Fong Dec. 28, 2015 Reprints Tags geneticsIVFreproductive medicine
Twitter Community New Arles road opens but disquiet over who was invited to official opening One man is due in court this morning following an attack against two people in Portlaoise at the weekend.As a result of Garda investigation, a male will appear at Portlaoise District Court today charged in connection with the incident.Gardai are still appealing for the public’s assistance with regards to the second male involved.Any person in a position to assist them should contact Portlaoise Garda Station at 057-8674100.During the incident a mobile phone and cash were stolen. The victims – one male and one female – are aged 17.The culprits are described as being aged in their 50s and 20s. The incident happened at approx 6.30pm at Millbrook, Portlaoise, which is close to the town’s Main Street.The mother of the girl attacked shared a post on Facebook describing the incident, saying it was dark at the time and that they shone a light into their face, threatening them with the knife if they didn’t give over their phones and money.She claimed the culprits weren’t interested in an iPhone and then fled the scene.The victims then alerted the Gardai.SEE ALSO – Zach Tuohy on nerves supporting Portlaoise, never watching the 2009 Leinster final and much more Facebook Pinterest Community Facebook TAGSknife Man due in court following attack at knife-point against two people in Portlaoise Charlie Flanagan on Electric Picnic: ‘I’d ask organisers to consult with community leaders’ WhatsApp Council By Alan Hartnett - 8th November 2018 RELATED ARTICLESMORE FROM AUTHOR Previous articleTable quiz to be held in aid of Portlaoise Hospital Special Care baby unitNext articleLaois footballers set to lose home league game following ‘breach of training camp rules’ Alan HartnettStradbally native Alan Hartnett is a graduate of Knockbeg College who has worked in the local and national media since 2008. Alan has a BA in Economics, Politics and Law and an MA in Journalism from DCU. His happiest moment was when Jody Dillon scored THAT goal in the Laois senior football final in 2016. Laois secondary school announces scholarship winners for new academic year Home News Man due in court following attack at knife-point against two people in... News WhatsApp Twitter Pinterest
Steve works across all of Mobile World Live’s channels and played a lead role in the launch and ongoing success of our apps and devices services. He has been a journalist...More Read more Steve Costello VimpelCom is set to sell its operations in Zimbabwe to a state-owned internet service provider (ISP).The deal has previously been mooted, with speculation that VimpelCom had found a foreign investor to buy the stake, before such a deal was blocked in order to allow ISP ZARnet into the frame.Global Telecom Holding, a company 51.9 per cent owned by VimpelCom, is to sell its stake in Telecel International for $40 million. In turn, Telecel owns 60 per cent of Telecel Zimbabwe.With VimpelCom having been an investor in Zimbabwe for a number of years, $40 million is hardly a handsome price (earlier this year a mobile infrastructure investment total of $237 million since 1998 was claimed). Its operation has also not been without headaches: earlier this year it had its licence suspended, although it subsequently got a reprieve.The transfer to ZARnet, which is wholly owned by the government through the ICT ministry, will take place “after customary conditions are satisfied”.VimpelCom has been in the process of disposing of a number of assets owned through Global Telecom Holding, including businesses in Algeria – after a long dispute – Burundi, Central African Republic and Canada. Money Previous ArticleMTS gets more optimistic about full-yearNext ArticlePandora to acquire $75M worth of assets from Rdio Related Zimbabwe reopens mobile money cash buying Author Home VimpelCom confirms Zimbabwe sale Zimbabwe mobile money cash-in services surge AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 18 NOV 2015 Zimbabwe slaps strict limits on mobile money Tags Global Telecom HoldingTelecelVimpelComZARnetZimbabwe
Deutsche Telekom is looking into options for its infrastructure assets, including mobile phone towers, such as a spinoff or an initial public offering.The move could value the assets “in the billions of dollars”, Bloomberg reported.Discussions are in their early stages and the company may decide to take no action at all, the report said.According to a company spokesman: “Deutsche Telekom is aware of what some of our competitors are doing in this respect, and we are considering what could make sense for us and what not.”These competitors include Telefonica, which set up a firm called Telxius to house its global infrastructure assets last month, a move reportedly being closely monitored by Deutsche Telekom.Meanwhile, Telecom Italia too is selling off its stake in Italian towers firm, Inwit.Such steps are usually taken to raise cash and lower expenses of maintaining networks.Last month, Thomas Dannenfeldt, Deutsche Telekom’s chief financial officer, speaking on a call with analysts, stated that “on the tower sales, I think it’s something we are investigating. It’s obvious and very clear that we have a very strong position here”, adding that the operator has “something like 40,000 cell sites in our European properties”. Author Saleha joined Mobile World Live in October 2014 as a reporter and works across all e-newsletters - creating content, writing blogs and reports as well as conducting feature interviews...More Read more Related Home Deutsche Telekom mulls towers spinoff or IPO – report Telefonica bolsters blockchain security Deutsche TelekomTelefonica Tags Saleha Riaz AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 11 MAR 2016 Telefónica refuerza la seguridad de las cadenas de bloques Español Luz verde a la fusión entre Telefónica y Liberty Global en el Reino Unido Previous ArticleFCC unveils mobile broadband privacy proposalsNext ArticleYouTube Gaming app heads to 4 more countries
Kavit joined Mobile World Live in May 2015 as Content Editor. He started his journalism career at the Press Association before joining Euromoney’s graduate scheme in April 2010. Read More >> Read more Canada’s number two operator BCE (Bell) announced a deal to acquire Manitoba Telecom Services (MTS) for C$3.9 billion ($3.1 billion), with a pledge to expand LTE in the province.The proposed deal, subject to regulatory approval, will see Bell significantly beef up its operations across western Canada, with the company committing to a $1 billion investment over five years to “expand broadband networks and services throughout Manitoba”.As part of the planned investment, Bell said it will accelerate expansion of MTS’ LTE network, “with average data speeds twice as fast as those now available”, as well as a focus on internet, TV and media services.In an apparent bid to curb regulatory concerns over the all-Canadian tie-up, and help fund the deal, Bell also said in a separate statement it will sell one third of MTS’ postpaid wireless subscribers and retail locations to rival (and number three player) Telus once the deal completes.Bell has just under 10 million connections according to GSMA Intelligence, while MTS’ wireless unit had 515,744 at the end of Q1 2016.“Welcoming MTS to the Bell group of companies opens new opportunities for unprecedented broadband communications investment, innovation and growth for urban and rural Manitoba locations alike,” said George Cope, president and CEO of BCE and Bell Canada.The purchase price for MTS will be approximately C$3.1 billion, and C$0.8 million in debt.The combined company will be known as Bell MTS, with Winnipeg set to become Bell’s headquarters for Western Canada.Bell said it expects to close the transaction at the end of 2016 or early 2017. Author Telus taps Google Cloud for 5G, MEC Home Canada’s Bell agrees $3.1B deal for rival Manitoba Telecom Services BCEBellManitoba Telecom ServicesTelus Previous ArticleIndia’s Idea has big picture on 4G, dataNext ArticleSprint points to positives despite widening quarterly loss Tags Telus to raise $1B as Canada 5G battle hots up Kavit Majithia AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 03 MAY 2016 Related Telus teams with Eseye for IoT boost
In its latest annual global risk assessment of MERS-CoV, the World Health Organization (WHO) said transmission, symptom profile, and virus characteristics haven't changed since its last report, but officials are still deeply concerned about transmission in hospitals.Since its last update in June 2018, 219 cases were reported in four countries: Saudi Arabia (204), Oman (13), South Korea (1), and the United Kingdom (1). However, of the 97 secondary cases reported to the WHO, 52 were linked to transmission in hospitals, including 23 infections in healthcare workers. Since the virus was first detected in humans in 2012, 2,449 cases have been reported through Jun 30, 84% of them in Saudi Arabia.Deep concern about hospital outbreaksThe virus is known to spread more easily in healthcare settings, and research is under way to better understand the factors that drive transmission.The WHO said awareness of the disease is still low, and the nonspecific early symptoms can make it difficult to identify cases. Gaps in infection prevention and control measures also contribute to disease spread. "Much more emphasis on improving standard IPC [infection prevention and control] practices in all health care facilities is required," the WHO said.Over the past year, a cluster of 61 cases in Wadi ad-Dawasir in February and March sickened 61 people, 14 of them health workers. The outbreak involved six healthcare facilities, and human-to-human spread occurred in two of them. Then in April, one of two unlinked clusters in Khafji resulted in 10 cases, 5 of them involving healthcare workers.Elsewhere, Oman reported two unlinked clusters in January and February, and one healthcare worker illness was reported in each of them.The main epidemiologic pattern for MERS-CoV (Middle East respiratory syndrome coronavirus) remains the same—many introductions from dromedary camels in the Middle East and secondary transmission in healthcare settings, the WHO said. Household transmission among close family members is still limited for unknown reasons, but healthcare-associated outbreaks in the region are occurring more often, are typically small, and can affect several hospitals.The WHO said though the risk of explosive outbreaks remains, "the recent exported cases in the United Kingdom and the Republic of Korea in August/September 2018 show us that human-to-human transmission and large outbreaks can be prevented with early suspicion, case isolation, and clinical management."Improvements, but challenges remainOf the 219 patients reported over the past year, 49 had asymptomatic or mild cases, according to the report, which added that the number of asymptomatic cases has increased since 2015 because of a Saudi health ministry policy change requiring that all high-risk contacts be tested for MERS-CoV. "This comprehensive contact identification, follow-up, testing, and isolation of positive cases continues into 2019," it said.In 145 (66.2%) of the cases, patient had at least one underlying health condition, the most common being chronic renal failure, heart disease, diabetes, and hypertension.The WHO said surveillance for MERS-CoV has significantly improved, especially in the Middle East, as has multisector investigation of community-acquired cases, including testing of dromedary camels in areas where human cases are detected. And aggressive investigation of cases and contacts and applying steps to stop human-to-human spread in hospitals are mitigating the size of outbreaks, it added.Ongoing challenges include early identification of cases in the community and in healthcare settings, compliance with IPC measures, and contact follow-up, according to the report.What's ahead for WHO technical teamThe new update also detailed the work of the WHO's MERS technical team over the past year and highlighted some of its current and planned activities. For example, the team posted new guidance documents, such as one on clinical management, and pushed forward with a research and development blueprint.According to the report, the WHO team and those involved with the blueprint are working on phase 2b/phase 3 clinical trial protocols to evaluate MERS-CoV therapies and vaccines.Also, experts are updating investigation tools to help countries during outbreaks. The WHO said it continues to support field-based studies—either in planning stages or already under way— to explore the extent of spillover from animals to humans in countries outside of the Arabian Peninsula, including Algeria, Egypt, Ethiopia, Pakistan, Somalia, and Sudan.See also:WHO July annual MERS-CoV risk assessmentAug 8, 2018, CIDRAP News story "WHO highlights ongoing hospital MERS risk"
Boskalis saw revenue increase slightly in the third quarter of 2019 compared to the quarterly average for the first half of the year.The order book stood at EUR4.2 billion (USD4.6 billion), slightly lower compared to the end of June. Over EUR500 million (USD550 million) of new contracts were signed in the third quarter, not including the recently awarded Changfang and Xidao offshore wind project in Taiwan.According to Boskalis, the utilisation of heavy transport vessels was stable compared to the first half of the year, while the project-specific assets (cable-laying, crane and fall pipe vessels) saw improvements.“The high-end transport market is starting to show cautious signs of recovery following a number of quiet years during which transport was wholly dependent on the spot market,” commented Boskalis.boskalis.com
The management of CSKA 1948 officially announced structural changes in the club. The team will follow the English model, and the coach Krassimir Balakov will be the general manager. Yordan Yurukov will have a bigger role in the preparation and training. Here is the message on the club’s website:“Due to the many information, rumors and speculations about the position of CSKA’s head coach – Krassimir Balakov, it is time to clarify what is happening at the club and the change in structure. CSKA is a team in which the decision has always been made not alone, but The club is in the first place, here we rely on the qualities and expertise of all individuals working for the interest and success of the “Army”.Taking into account this line of development, Krassimir Balakov and Yordan Yurukov will continue to work together in a team led by CSKA. In addition to his role as head coach, Balakov also takes on a managerial position. He will be the link between the coaching staff and the management of CSKA in the person of the Sports Director – Kiril Kotev, the Executive Director – Dobrin Gonov, as well as the Board of Directors of the club.The restructuring is carried out according to the English model in order to – greater freedom of Krassimir Balakov in making decisions in the club, providing peace of mind for analysis of the work process and maximum contribution to the development of CSKA. Yordan Yurukov, for his part, gets an even more significant role in the preparation and training process of the “reds” for the upcoming matches of the efbet League and the Cup of Bulgaria. ”Change in CSKA 1948 – Balakov became general manager and Yurukov – coach
By JARROD POTTER CALLING in the big guns to coach the next generation of female soccer talent, former Matilda Debbie...[To read the rest of this story Subscribe or Login to the Gazette Access Pass] Thanks for reading the Pakenham Berwick Gazette. Subscribe or Login to read the rest of this content with the Gazette Digital Access Pass subscription.
By BEN CAMERON AN EMERALD environmental group has called for greater transparency over the Cardinia Shire Council’s new energy plan....[To read the rest of this story Subscribe or Login to the Gazette Access Pass] Thanks for reading the Pakenham Berwick Gazette. Subscribe or Login to read the rest of this content with the Gazette Digital Access Pass subscription.